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Increased Pain Sensitivity to Intraoral Capsaicin in Patients with Atypical Odontalgia
Department of Clinical Oral Physiology, School of Dentistry, University of Aarhus, Aarhus, Denmark.
Malmö högskola, Faculty of Odontology (OD).ORCID iD: 0000-0002-9638-4648
Danish Pain Research Center, Aarhus University Hospital, Aarhus, Denmark.
Department of Clinical Oral Physiology, School of Dentistry, University of Aarhus, Aarhus, Denmark; Department of Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark; Center for Sensory-Motor Interaction, Aalborg University, Aalborg, Denmark.ORCID iD: 0000-0001-5809-8037
2006 (English)In: Journal of Orofacial Pain, ISSN 1064-6655, E-ISSN 1945-3396, Vol. 20, no 2, p. 107-114Article in journal (Refereed) Published
Abstract [en]

AIMS: To use 2 well-characterized stimuli, the intraoral capsaicin model and the "nociceptive-specific" electrode, to compare superficial nociceptive function between patients with atypical odontalgia (AO) and matched healthy controls. Furthermore, the authors aimed to describe the sensitivity, specificity, and positive predictive values (PPV) of the techniques if group differences could be established. METHODS: Thirty-eight patients with AO and 27 matched healthy controls participated in this study. Thirty microliters of 5% capsaicin was applied to the gingiva on the left and right sides of all participants as a pain-provocation test. The participants scored the capsaicin-evoked pain continuously on a 0-to-10 visual analog scale (VAS). Furthermore, individual electrical sensory and pain thresholds to stimulation with a "nociceptive-specific" electrode on the facial skin above the infraorbital or mental nerve were determined. RESULTS: AO patients had higher VAS pain scores for capsaicin application than healthy controls (ANOVA: F > 4.88; P < .029). No differences between the painful sides and the nonpainful sides of the patients were found (ANOVA: F < 1.26; P > .262). No main effects of group or stimulation side on the electrical sensory and pain thresholds were detected (ANOVA: F < 0.309; P > .579). Sensitivity was 0.51; specificity, 0.81; and PPV, 0.77 when a VAS value of > or = 8 for capsaicin-evoked pain was used. CONCLUSION: AO patients show increased sensitivity to intraoral capsaicin but normal sensitivity to "nociceptive-specific" electrical stimulation of the face in an area proximal to the painful site. The use of the intraoral pain-provocation test with capsaicin as a possible adjunct to the diagnostic workup is hampered by the only moderately good sensitivity and specificity.

Place, publisher, year, edition, pages
Quintessence , 2006. Vol. 20, no 2, p. 107-114
National Category
Dentistry
Identifiers
URN: urn:nbn:se:mau:diva-15779ISI: 000237330500004PubMedID: 16708828Scopus ID: 2-s2.0-33646823143Local ID: 3722OAI: oai:DiVA.org:mau-15779DiVA, id: diva2:1419301
Available from: 2020-03-30 Created: 2020-03-30 Last updated: 2024-06-19Bibliographically approved

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