This prospective study evaluated clinical results of immediately loaded Biomet 3i implants with different surface topographies. Thirty-three periodontally compromised patients received 163 implants (130 in the maxilla and 33 in the mandible; 132 NanoTite and 31 Osseotite). After a mean loading period of 57 months, the survival rate was 96.3%. Mean crestal bone loss was 1.6 mm. No difference in bone loss was detected between the two surfaces. Only 6% of the implants had peri-implantitis based on total bone loss above 2 mm from the day of surgery in conjunction with probing depths of > 4 mm.