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LPS induces GROα chemokine production via NFκB in oral fibroblasts
Malmö högskola, Faculty of Odontology (OD).ORCID iD: 0000-0001-8298-539X
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2009 (English)In: Inflammation Research, ISSN 1023-3830, E-ISSN 1420-908X, Vol. 11, no 58, p. 791-796Article in journal (Refereed)
Abstract [en]

OBJECTIVE AND DESIGN: Chemotaxis of neutrophils from blood to the inflammation process plays an important role in development of periodontal inflammation. The novel chemokine GROalpha, also named CXCL1, is a strong chemoattractant for neutrophils. Data on production and regulation of GROalpha by oral fibroblasts have not previously been presented. MATERIALS AND METHODS: GROalpha mRNA and protein levels were determined in human periodontal ligament cells and mouse gingival fibroblasts by quantitative real-time PCR and ELISA. RESULTS: We disclose that both human periodontal ligament cells and mouse gingival fibroblasts produce GROalpha in response to LPS stimulation. Stimulation with LPS for 24 h increased both mRNA for GROalpha and GROalpha protein. The steroid hormone estrogen had no effect on LPS-induced GROalpha mRNA expression. Treatment with the glucocorticoid dexamethasone attenuated LPS-induced GROalpha production, and the NF-kappaB blocker MG 132 fully prevented LPS-induced GROalpha. CONCLUSIONS: Oral fibroblasts respond to LPS stimulation by increasing GROalpha production via the transcription factor NF-kappaB, suggesting that this mechanism may be involved in development of periodontal inflammation.

Place, publisher, year, edition, pages
Springer, 2009. Vol. 11, no 58, p. 791-796
Keywords [en]
Chemokines, Dexamethasone, Estrogen, GROα, PDL cells
National Category
Dentistry
Identifiers
URN: urn:nbn:se:mau:diva-15426DOI: 10.1007/s00011-009-0049-zISI: 000270652900008PubMedID: 19430878Scopus ID: 2-s2.0-70349917579Local ID: 15976OAI: oai:DiVA.org:mau-15426DiVA, id: diva2:1418947
Available from: 2020-03-30 Created: 2020-03-30 Last updated: 2024-02-05Bibliographically approved

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Jönsson, Daniel

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