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Poly-L-lysine/heparin multilayer coatings prevent blood protein adsorption
Malmö högskola, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Department of Biomaterials, Institute of Clinical Dentistry, University of Oslo, P.O. Box 1109 Blindern, 0317 Oslo, Norway.ORCID iD: 0000-0002-1489-4098
Department of Biomaterials, Institute of Clinical Dentistry, University of Oslo, P.O. Box 1109 Blindern, 0317 Oslo, Norway.
Malmö högskola, Faculty of Health and Society (HS), Department of Biomedical Science (BMV).
Department of Biomaterials, Institute of Clinical Dentistry, University of Oslo, P.O. Box 1109 Blindern, 0317 Oslo, Norway.
2017 (English)In: Journal of Colloid and Interface Science, ISSN 0021-9797, E-ISSN 1095-7103, Vol. 485, p. 288-295Article in journal (Refereed) Published
Abstract [en]

The adsorption of blood proteins, serum albumin (BSA), immunoglobulin G (IgG) and fibrinogen (FGN), onto model SiO2 planar surfaces coated with poly-L-lysine/heparin multilayers (PLL/HEP) has been investigated by means of ellipsometry and quartz crystal microbalance with dissipation. Aiming at the development of low fouling coatings, this study has been focused on the effects that the number of layers and the type of polyelectrolyte present on the topmost layer have on the adsorption of these proteins. The three proteins interact with PLL-ended coatings whereas HEP-ended coatings prevent the adsorption of both BSA and IgG and induce a decrease in the adsorbed amount of FGN, down to 0.4 mg/m(2) for three bilayers, as the number of PLL/HEP bilayers increases. These results suggest that heparin-ended multilayers prevent protein adsorption, which is an indicative of good blood compatibility. As a consequence we propose that PLL/HEP coatings could be used for the development of vascular medical devices. (C) 2016 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 485, p. 288-295
Keywords [en]
Layer by layer, Protein adsorption, Ellipsometry, QCM-D, Heparin coating
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:mau:diva-15182DOI: 10.1016/j.jcis.2016.09.046ISI: 000385900400035PubMedID: 27684786Scopus ID: 2-s2.0-84988689690Local ID: 23349OAI: oai:DiVA.org:mau-15182DiVA, id: diva2:1418703
Available from: 2020-03-30 Created: 2020-03-30 Last updated: 2024-06-17Bibliographically approved

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Barrantes, AlejandroArnebrant, Thomas

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