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An Epitope Imprinted Biointerface with Dynamic Bioactivity for Modulating Cell-Biomaterial Interactions
Malmö högskola, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Malmö högskola, Biofilms Research Center for Biointerfaces. Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, Zhenjiang, Jiangsu, 212013, China.
Malmö högskola, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Malmö högskola, Biofilms Research Center for Biointerfaces.ORCID iD: 0000-0001-9460-0936
Malmö högskola, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Malmö högskola, Biofilms Research Center for Biointerfaces.
Malmö högskola, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Malmö högskola, Biofilms Research Center for Biointerfaces.
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2017 (English)In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 56, no 50, p. 15959-15963Article in journal (Refereed)
Abstract [en]

In this study, an epitope-imprinting strategy was employed for the dynamic display of bioactive ligands on a material interface. An imprinted surface was initially designed to exhibit specific affinity towards a short peptide (i.e., the epitope). This surface was subsequently used to anchor an epitope-tagged cell-adhesive peptide ligand (RGD: Arg-Gly-Asp). Owing to reversible epitope-binding affinity, ligand presentation and thereby cell adhesion could be controlled. As compared to current strategies for the fabrication of dynamic biointerfaces, for example, through reversible covalent or host–guest interactions, such a molecularly tunable dynamic system based on a surface-imprinting process may unlock new applications in in situ cell biology, diagnostics, and regenerative medicine.

Place, publisher, year, edition, pages
John Wiley & Sons, 2017. Vol. 56, no 50, p. 15959-15963
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Natural Sciences
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URN: urn:nbn:se:mau:diva-14809DOI: 10.1002/anie.201708635ISI: 000417200600028PubMedID: 28960837Scopus ID: 2-s2.0-85031407608Local ID: 24189OAI: oai:DiVA.org:mau-14809DiVA, id: diva2:1418330
Available from: 2020-03-30 Created: 2020-03-30 Last updated: 2024-06-17Bibliographically approved

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Publisher's full textPubMedScopushttp://rdcu.be/C5nF/

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Shinde, SudhirkumarYeung, Sing YeeLi, QianjinGjörloff Wingren, AnetteSellergren, Börje

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Shinde, SudhirkumarYeung, Sing YeeLi, QianjinGjörloff Wingren, AnetteSellergren, Börje
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