We present results from a research project aiming at investigating how students in lower secondary school experience work with socio-scientific issues (SSI). The socio-scientific cases developed and used in this project are relevant according to characteristics of SSI and to the national curriculum. Approximately 1600 students in Sweden have worked with one or several SSI cases. A questionnaire-based instrument was used to measure the affective domain of students’ attitudes towards and interest in science before starting to work with the case and a second questionnaire after finishing a case. According to the students’ self-reported experience, all cases were interesting and related to a current issue. Most cases were equally interesting to boys and girls, the only exception was ”You are what you eat”, which girls found more interesting than boys did. Almost all students claim that they learnt new facts, learnt to argue for their standpoint and to search and scrutinize information during the work with the cases. They do not, however, claim that they learnt more science than during ordinary lessons. This research project will continue with a qualitative approach studying classroom work with SSI to ascertain the link between SSI curricula and the learning of science content.