Introduction: People with diabetes type 1 (DT1) and 2 (DT2) develop complications on small and large vessels and nerve pathways over time. In men with Diabetes, erectile dysfunction is a well-documented complication. However, knowledge about sexual dysfunction in women with diabetes is less studied and available studies do not distinguish between DT1 and DT2. In addition sexual dysfunction are associated with lowered health-related quality of life and depressive symptoms. Objective: The aim of this study was to conduct a cross-sectional study among women with type 1 diabetes on sexual function and health-related issues. Method: A cross-sectional study with a self-reporting questionnaire including validated instruments and background questions. Study population is women residing in southern Sweden aged 45-70 with diabetes type 1 for at least 15 years. The women were identified from clinical electronic medical records at two hospitals. Sexual function by Female Sexual Function Index (FSFI) was included. Depression was investigated by Patient Health Questionnaire (PHQ-9). A descriptive statistical analysis of background factors, depression and self-reported occurrence of sexual dysfunction is presented. An 80% power calculation at p < 0.05 based on a study population of 356 women was applied and data collection is ongoing. The Regional Ethics and Research Board approved the study (No. 2018/855). Results: By April 2019, in total 84 women have returned a completed questionnaire. Mean age was 53.5 years (SD: 9.3), mean years with DT1 was 35.5 years (SD: 11.4) and BMI was 27.1 (SD: 4.8). Sexual dysfunction with the cut-off score less than 26.0 (a maximum score at 36) was reported by 39.3% of the women. The sub-score (value 2-6) of five domains showed the lowest value for Desire 3.0, followed by Arousal 3.6, Lubrication 3.8, Orgasm 3.9, Pain 4.0 and Satisfaction 4.1. In total 38.6% reported mild or moderate to severe symptoms of depression measured with PHQ-9. However, only 33.3% of those with depressive symptoms reported having anti-depressive medication. Conclusions: Women with a long-term DT1 diagnosis showed symptoms of both sexual dysfunction and depression. Therefore, these problems in women with DT1 can be unreported unless addressed on a regular basis. Self-reported instruments such as FSFI and PHQ-9 has shown good validity to screen for these conditions and could be used for assessment within gynecological and primary health care as well as at mental health clinics caring for women with DT1.