This chapter discusses special child patients with disabilities or chronic health conditions and provides examples to assist with their management in the dental office. It focuses on how the dental team can work together with the child and family to create positive dental appointments and good oral health. The convention noted changing societal views on people with disabilities. Cognitive reasoning, behavioral repertoires, and communicative skills vary, especially in children with disabilities. People with disabilities may be subject to inequality in oral health, in terms of both prevalence of disease and unmet healthcare needs. Children with intellectual disabilities are slower in acquiring self-care life-skills, have difficulty remembering things, and have delayed language development. Interpretation using sign language might be necessary and should be offered if available. The dentist should know how to communicate with sign language. Dentists who are motivated to treat special children will find it both stimulating and rewarding.