In this chapter, contributors address the core challenges of collaborating across academic divisions such as humanities and science, bridging academic and community practices, and translating between the diverse stakeholders involved in these projects. Much of the recent research on problem-based collaboration and innovation has noted the value of bringing together teams of people with radically different forms of expertise to solve complex challenges (Johnson 2010; Davidson 2011; Ness 2012). Contributors address a common question asked by academics interested in applied media studies, who don’t know where to begin: how do you find good collaborators in different, perhaps unfamiliar disciplines? Further, once those collaborators are found, how do you overcome the typical siloes of universities structured by departments within divisions like “humanities” and “sciences” to build effective working relationships with your collaborators? How do you translate between fields with radically different training, terminology, and theories of knowledge? What does it take to develop a shared vocabulary?