Malmö University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Vitamin D status and dental caries in healthy Swedish children
Malmö University, Faculty of Odontology (OD).ORCID iD: 0000-0002-4501-6976
Show others and affiliations
2018 (English)In: Nutrition Journal, ISSN 1475-2891, E-ISSN 1475-2891, Vol. 17Article in journal (Refereed)
Abstract [en]

Background: Vitamin D is crucial for mineralized tissue formation and immunological functions. The purpose of this study was to evaluate the association between vitamin D status and dental status in healthy children with vitamin D supplementation in infancy and at 6 years of age. Method: Eight-year-old children who had participated, in a vitamin D intervention project when they were 6 years old were invited to participate in a dental follow-up study. They had fair or darker skin complexion and represented two geographically distant parts of Sweden. 25-hydroxy vitamin D in serum had been measured at 6 years of age and after a 3-month intervention with 25, 10 or 2 (placebo) mu g of vitamin D-3 per day. Two years later, caries and enamel defects were scored, self-reported information on e.g., oral behavior, dietary habits and intake of vitamin D supplements was collected, and innate immunity peptide LL37 levels in saliva and cariogenic mutant streptococci in tooth biofilm were analyzed. The outcome variables were caries and tooth enamel defects. Results: Dental status was evaluated in 85 of the 206 children in the basic intervention study. Low vitamin D levels were found in 28% at baseline compared to 11% after the intervention, and 34% reported continued intake of vitamin D supplements. Logistic regression supported a weak inverse association between vitamin D status at 6 years of age and caries 2 years later (odds ratio 0.96; p = 0.024) with minor attenuation after an adjustment for potential confounders. Multivariate projection regression confirmed that insufficient vitamin D levels correlated with caries and higher vitamin D levels correlated with being caries-free. Vitamin D status at 6 years of age was unrelated to enamel defects but was positively associated with saliva LL37 levels. Conclusion: An association between vitamin D status and caries was supported, but it was not completely consistent. Vitamin D status at 6 years of age was unrelated to enamel defects but was positively associated with LL37 expression.

Place, publisher, year, edition, pages
BioMed Central, 2018. Vol. 17
Keywords [en]
Vitamin D, Children, caries, enamel defects, LL37
National Category
Dentistry
Identifiers
URN: urn:nbn:se:mau:diva-7166DOI: 10.1186/s12937-018-0318-1ISI: 000419960300001PubMedID: 29338758Scopus ID: 2-s2.0-85040828698Local ID: 25829OAI: oai:DiVA.org:mau-7166DiVA, id: diva2:1404120
Available from: 2020-02-28 Created: 2020-02-28 Last updated: 2024-02-05Bibliographically approved

Open Access in DiVA

fulltext(627 kB)107 downloads
File information
File name FULLTEXT01.pdfFile size 627 kBChecksum SHA-512
f4e4014a4b877080cc44f762de6d1b04f7387e75d39ce2920d7d7f60ac9529fa14980d14d4ed1f1e1cb51e1e49027926f5588997ebd0bebdbf5c23b306930fe7
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Ridell, Karin

Search in DiVA

By author/editor
Ridell, Karin
By organisation
Faculty of Odontology (OD)
In the same journal
Nutrition Journal
Dentistry

Search outside of DiVA

GoogleGoogle Scholar
Total: 107 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 60 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf