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Analgesic efficacy and clinical acceptability of adjunct pre-emptive intravenous tramadol in midazolam sedation for third molar surgery
Malmö högskola, Faculty of Odontology (OD).
Malmö högskola, Faculty of Odontology (OD).ORCID iD: 0000-0002-2812-5409
2013 (English)In: Oral and Maxillofacial Surgery, ISSN 1865-1550, E-ISSN 1865-1569, Vol. 17, no 3, p. 193-199Article in journal (Refereed) Published
Abstract [en]

Introduction This study aims to compare two routine procedures of sedation, with and without intravenous adjunct analgesia, in third molar surgery regarding postoperative pain and consumption of analgesics. Material and methods In a randomized, controlled, single-blinded procedure, 87 men and women aged 18–44 years were divided into two treatment groups, midazolam + tramadol (M + T) and midazolam + saline (M + S), and one control group (C), with no additional medication. After removal of a third lower molar, patients recorded postoperative pain on a visual analog scale (VAS) and consumption of analgesics during the first day after surgery. Results Time from the end of operation until first rescue pill (400 mg Ibuprofen tablet) differed significantly between the M + S group (193 min) and the C group (110 min) (p = 0.001) as well as the M + T group (157 min) and the C group (p = 0.049). The study did not show any significant reduction of postoperative pain, VAS, after third molar surgery in patients who received adjunct pre-emptive intravenous administration of 1 mg/kg tramadol under midazolam sedation. Discussion and conclusion The lack of significant difference between the study and placebo groups indicates that tramadol at 1 mg/kg might be an insufficient dose, though the suitability for tramadol in oral and maxillofacial surgery has already been settled in other studies.

Place, publisher, year, edition, pages
Springer, 2013. Vol. 17, no 3, p. 193-199
Keywords [en]
Tramadol, Postoperative analgesia, Midazolam, Third molar surgery, Pain
National Category
Dentistry
Identifiers
URN: urn:nbn:se:mau:diva-6626DOI: 10.1007/s10006-012-0359-0ISI: 000218350200006PubMedID: 22971742Scopus ID: 2-s2.0-84881558362Local ID: 15666OAI: oai:DiVA.org:mau-6626DiVA, id: diva2:1403571
Available from: 2020-02-28 Created: 2020-02-28 Last updated: 2024-11-19Bibliographically approved

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Eriksson, LarsTegelberg, Åke

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