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Time-resolved small-angle neutron scattering as a probe for the dynamics of lipid exchange between human lipoproteins and naturally derived membranes
Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV).ORCID iD: 0000-0001-6547-5427
Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV).
Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Singapore.
Dept. of Clinical Sciences, Lund University, Jan Waldenströms gata 35, CRC, Box 50332, 212 13, Malmö, Sweden.
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2019 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 9, no 1, article id 7591Article in journal (Refereed) Published
Abstract [en]

Atherosclerosis is the main killer in the western world. Today's clinical markers include the total level of cholesterol and high-/low-density lipoproteins, which often fails to accurately predict the disease. The relationship between the lipid exchange capacity and lipoprotein structure should explain the extent by which they release or accept lipid cargo and should relate to the risk for developing atherosclerosis. Here, small-angle neutron scattering and tailored deuteration have been used to follow the molecular lipid exchange between human lipoprotein particles and cellular membrane mimics made of natural, "neutron invisible" phosphatidylcholines. We show that lipid exchange occurs via two different processes that include lipid transfer via collision and upon direct particle tethering to the membrane, and that high-density lipoprotein excels at exchanging the human-like unsaturated phosphatidylcholine. By mapping the specific lipid content and level of glycation/oxidation, the mode of action of specific lipoproteins can now be deciphered. This information can prove important for the development of improved diagnostic tools and in the treatment of atherosclerosis.

Place, publisher, year, edition, pages
Nature Publishing Group, 2019. Vol. 9, no 1, article id 7591
Keywords [en]
Multidisciplinary Sciences
National Category
Cardiac and Cardiovascular Systems
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URN: urn:nbn:se:mau:diva-4549DOI: 10.1038/s41598-019-43713-6ISI: 000468281500021PubMedID: 31110185Scopus ID: 2-s2.0-85066021599Local ID: 30138OAI: oai:DiVA.org:mau-4549DiVA, id: diva2:1401381
Available from: 2020-02-28 Created: 2020-02-28 Last updated: 2023-08-31Bibliographically approved

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Maric, SelmaLind, Tania KjellerupArnebrant, ThomasCárdenas, Marité

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