Sensing by wireless reading Ag/AgCl redox conversion on RFID tag: universal, battery-less biosensor designShow others and affiliations
2019 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 9, article id 12948Article in journal (Refereed) Published
Abstract [en]
Massive integration of biosensors into design of Internet-of-Things (IoT) is vital for progress of healthcare. However, the integration of biosensors is challenging due to limited availability of battery-less biosensor designs. In this work, a combination of nanomaterials for wireless sensing of biological redox reactions is described. The design exploits silver nanoparticles (AgNPs) as part of the RFID tag antenna. We demonstrate that a redox enzyme, particularly, horseradish peroxidase (HRP), can convert AgNPs into AgCl in the presence of its substrate, hydrogen peroxide. This strongly changes the impedance of the tag. The presented example exploits gold nanoparticle (AuNP)-assisted electron transfer (ET) between AgNPs and HRP. We show that AuNP is a vital intermediate for establishing rapid ET between the enzyme and AgNPs. As an example, battery-less biosensor-RFID tag designs for H2O2 and glucose are demonstrated. Similar battery-less sensors can be constructed to sense redox reactions catalysed by other oxidoreductase enzymes, their combinations, bacteria or other biological and even non-biological catalysts. In this work, a fast and general route for converting a high number of redox reaction based sensors into battery-less sensor-RFID tags is described.
Place, publisher, year, edition, pages
Nature Publishing Group, 2019. Vol. 9, article id 12948
Keywords [en]
Multidisciplinary Sciences
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:mau:diva-3963DOI: 10.1038/s41598-019-49245-3ISI: 000484984700023PubMedID: 31506441Scopus ID: 2-s2.0-85072038367Local ID: 30524OAI: oai:DiVA.org:mau-3963DiVA, id: diva2:1400787
2020-02-282020-02-282024-08-02Bibliographically approved