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Sensing by wireless reading Ag/AgCl redox conversion on RFID tag: universal, battery-less biosensor design
Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Malmö University, Biofilms Research Center for Biointerfaces. Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Patumwan, 10330, Bangkok, Thailand.
Malmö University, Biofilms Research Center for Biointerfaces. Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV).
Malmö University, Biofilms Research Center for Biointerfaces. Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran.
Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Malmö University, Biofilms Research Center for Biointerfaces.ORCID iD: 0000-0001-5518-4095
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2019 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 9, article id 12948Article in journal (Refereed) Published
Abstract [en]

Massive integration of biosensors into design of Internet-of-Things (IoT) is vital for progress of healthcare. However, the integration of biosensors is challenging due to limited availability of battery-less biosensor designs. In this work, a combination of nanomaterials for wireless sensing of biological redox reactions is described. The design exploits silver nanoparticles (AgNPs) as part of the RFID tag antenna. We demonstrate that a redox enzyme, particularly, horseradish peroxidase (HRP), can convert AgNPs into AgCl in the presence of its substrate, hydrogen peroxide. This strongly changes the impedance of the tag. The presented example exploits gold nanoparticle (AuNP)-assisted electron transfer (ET) between AgNPs and HRP. We show that AuNP is a vital intermediate for establishing rapid ET between the enzyme and AgNPs. As an example, battery-less biosensor-RFID tag designs for H2O2 and glucose are demonstrated. Similar battery-less sensors can be constructed to sense redox reactions catalysed by other oxidoreductase enzymes, their combinations, bacteria or other biological and even non-biological catalysts. In this work, a fast and general route for converting a high number of redox reaction based sensors into battery-less sensor-RFID tags is described.

Place, publisher, year, edition, pages
Nature Publishing Group, 2019. Vol. 9, article id 12948
Keywords [en]
Multidisciplinary Sciences
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Natural Sciences
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URN: urn:nbn:se:mau:diva-3963DOI: 10.1038/s41598-019-49245-3ISI: 000484984700023PubMedID: 31506441Scopus ID: 2-s2.0-85072038367Local ID: 30524OAI: oai:DiVA.org:mau-3963DiVA, id: diva2:1400787
Available from: 2020-02-28 Created: 2020-02-28 Last updated: 2024-08-02Bibliographically approved

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Shafaat, AtefehGonzalez-Martinez, Juan FSotres, JavierArnebrant, ThomasRuzgas, Tautgirdas

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