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Effect of Protection Polymer Coatings on the Performance of an Amperometric Galactose Biosensor in Human Plasma
CSIC, Inst Catalisis & Petroleoquim, C-Marie Curie 2, Madrid 28049, Spain..
Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Malmö University, Biofilms Research Center for Biointerfaces. Aptusens AB, S-29394 Kyrkhult, Sweden..
Univ Galway, Sch Biol & Chem Sci, Galway H91 TK33, Ireland.;Univ Galway, Ryan Inst, Galway H91 TK33, Ireland..
Ruhr Univ Bochum, Fac Chem & Biochem, Analyt Chem Ctr Electrochem Sci CES, D-44791 Bochum, Germany..
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2024 (English)In: Biosensors, ISSN 2079-6374, Vol. 14, no 4, article id 167Article in journal (Refereed) Published
Abstract [en]

Galactose monitoring in individuals allows the prevention of harsh health conditions related to hereditary metabolic diseases like galactosemia. Current methods of galactose detection need development to obtain cheaper, more reliable, and more specific sensors. Enzyme-containing amperometric sensors based on galactose oxidase activity are a promising approach, which can be enhanced by means of their inclusion in a redox polymer coating. This strategy simultaneously allows the immobilization of the biocatalyst to the electroactive surface and hosts the electron shuttling units. An additional deposition of capping polymers prevents external interferences like ascorbic or uric acid as well as biofouling when measuring in physiological fuels. This work studies the protection effect of poly(2-methacryloyloxyethyl phosphorylcholine-co-glycidyl methacrylate (MPC) and polyvinylimidazole-polysulfostyrene (P(VI-SS)) when incorporated in the biosensor design for the detection of galactose in human plasma.

Place, publisher, year, edition, pages
2024. Vol. 14, no 4, article id 167
Keywords [en]
galactose, biosensor, plasma, protection polymers
National Category
Chemical Sciences
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URN: urn:nbn:se:mau:diva-67293DOI: 10.3390/bios14040167ISI: 001210296900001PubMedID: 38667160Scopus ID: 2-s2.0-85191463455OAI: oai:DiVA.org:mau-67293DiVA, id: diva2:1859024
Available from: 2024-05-20 Created: 2024-05-20 Last updated: 2024-05-20Bibliographically approved

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Psotta, CarolinFalk, MagnusShleev, Sergey

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Psotta, CarolinSchuhmann, WolfgangLeech, DonalFalk, MagnusPita, MarcosShleev, Sergey
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