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Health Related Quality of Life Following Intervention for Thoracoabdominal Aortic Aneurysm: a Systematic Review and Narrative Synthesis
Vascular Surgery Department, Imperial College Healthcare NHS Trust, London, UK; Faculty of Medicine, Department of Surgery & Cancer, Imperial College London, London, UK.
Vascular Surgery Department, Imperial College Healthcare NHS Trust, London, UK; Faculty of Medicine, Department of Surgery & Cancer, Imperial College London, London, UK.
Vascular Surgery Department, Imperial College Healthcare NHS Trust, London, UK; Faculty of Medicine, Department of Surgery & Cancer, Imperial College London, London, UK.
Malmö University, Faculty of Health and Society (HS), Department of Care Science (VV). Department of Cardiothoracic and Vascular Surgery, Skåne University Hospital, 214 28 Malmö, Sweden.ORCID iD: 0000-0002-1437-5060
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2024 (English)In: Annals of Vascular Surgery, ISSN 0890-5096, E-ISSN 1615-5947, Vol. 101, p. 105-119, article id S0890-5096(23)00860-9Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Thoracoabdominal aortic aneurysms (TAAA) pose significant risks of morbidity and mortality. Considering the evolving techniques for TAAA intervention and the growing interest in quality of life (QoL) outcomes for decision-making, we aimed to evaluate the impact of patient and perioperative characteristics on short-, medium-, and long-term post-operative QoL in TAAA repair patients.

METHODS: A systematic search was conducted in CINAHL, APA PsycINFO, EMBASE, Medline and Cochrane to identify primary research studies evaluating QoL post TAAA surgery, published in English or Swedish between 01 January 2012 and 26 September 2022. A narrative synthesis was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. The quality of evidence was assessed using the Critical Appraisal Skills Programme and Joanna Briggs Institute checklists.

RESULTS: Eight studies of low or moderate quality with 455 patients were included. Preoperative QoL in TAAA patients was lower compared to the general population. While there is an initial short-term improvement in post-operative QoL, patients fail to reach baseline levels even after seven years, with physical activity and functioning domains being particularly affected. Experiencing post-operative complications, including paraplegia and cardiovascular events, negatively impacts post-operative QoL. Patients with uncomplicated postoperative status had improved QoL. Prolonged hospital stay negatively affects physical functioning.

CONCLUSIONS: Individuals with TAAA are likely to have lower baseline QoL compared to the general population. Following TAAA repair, post-operative QoL may remain lower than baseline levels, persisting over the long-term. Comorbidities, post-operative complications, and hospitalisation duration appear to exert adverse effects on post-operative QoL.

Place, publisher, year, edition, pages
Elsevier, 2024. Vol. 101, p. 105-119, article id S0890-5096(23)00860-9
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Cardiac and Cardiovascular Systems
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URN: urn:nbn:se:mau:diva-64861DOI: 10.1016/j.avsg.2023.10.032ISI: 001170594700001PubMedID: 38160705Scopus ID: 2-s2.0-85183110300OAI: oai:DiVA.org:mau-64861DiVA, id: diva2:1824858
Available from: 2024-01-08 Created: 2024-01-08 Last updated: 2024-03-28Bibliographically approved

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Kumlien, Christine

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