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Review of structural design guiding the development of lipid nanoparticles for nucleic acid delivery
Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Malmö University, Biofilms Research Center for Biointerfaces. Univ Basque Country & Consejo Super Invest Cient, Biofis Inst, UPV EHU CSIC, Leioa 48940, Spain.;Basque Fdn Sci, IKERBASQUE, Bilbao, Spain..ORCID iD: 0000-0003-0392-3540
Univ Manchester, Fac Biol Med & Hlth, Div Pharm & Optometry, Manchester M13 9PT, England..ORCID iD: 0000-0002-6296-314X
AstraZeneca, Adv Drug Delivery Pharmaceut Sci, R&D, S-43183 Gothenburg, Sweden..
Univ Manchester, Fac Biol Med & Hlth, Div Pharm & Optometry, Manchester M13 9PT, England..
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2023 (English)In: Current Opinion in Colloid & Interface Science, ISSN 1359-0294, E-ISSN 1879-0399, Vol. 66, article id 101705Article, review/survey (Refereed) Published
Abstract [en]

Lipid nanoparticles (LNPs) are the most versatile and successful gene delivery systems, notably highlighted by their use in vaccines against COVID-19. LNPs have a well-defined core-shell structure, each region with its own distinctive compositions, suited for a wide range of in vivo delivery applications. Here, we discuss how a detailed knowledge of LNP structure can guide LNP formulation to improve the efficiency of delivery of their nucleic acid payload. Perspectives are detailed on how LNP structural design can guide more efficient nucleic acid transfection. Views on key physical characterization techniques needed for such developments are outlined including opinions on biophysical approaches both correlating structure with functionality in biological fluids and improving their ability to escape the endosome and deliver they payload.

Place, publisher, year, edition, pages
Elsevier, 2023. Vol. 66, article id 101705
Keywords [en]
Lipid nanoparticles, Nucleic acid delicery, Structure-function, Cationic
National Category
Biophysics
Identifiers
URN: urn:nbn:se:mau:diva-61924DOI: 10.1016/j.cocis.2023.101705ISI: 001025798000001Scopus ID: 2-s2.0-85162178818OAI: oai:DiVA.org:mau-61924DiVA, id: diva2:1788560
Available from: 2023-08-16 Created: 2023-08-16 Last updated: 2023-08-16Bibliographically approved

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Cárdenas, Marité

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