Because new zirconia materials are constantly being developed, the aim was to identify and qualitatively synthesize research on how processing and time-related factors affect the properties of high translucent (HT) zirconia intended for monolithic restorations. Cochrane Library, PubMed, Scopus, Web of Science, and reference lists were searched for in vitro and clinical studies. Eligibility and risk of bias were assessed. A synthesis of 142 publications was performed. HT 3Y-TZP was the most common, followed by 5YSZ, 4YSZ, and multilayer. In the laboratory, HT 3Y-TZP should be sintered according to the manufacturer’s recommendation and polished before glazing to favour strength, roughness, and wear behaviour. In the clinic, polishing is necessary after grinding to favour roughness and aging resistance. Over time, when using hydrothermal aging, t–m phase transformation and reduced translucency are expected, without affecting the strength and roughness. The strength of 4YSZ and 5YSZ is unaffected. However, the time-related methods are of questionable clinical significance. The evidence of all other factors’ effects on the properties of HT zirconia is lacking or limited; thus, these factors are of relevance for future research. There is a high heterogeneity of study designs and methods, and the results are brand-dependent.