Publikationer från Malmö universitet
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
AKVANO (R): A Novel Lipid Formulation System for Topical Drug Delivery-In Vitro Studies
Lipidor AB, Svardvagen 13, SE-18233 Danderyd, Sweden.;Stockholm Univ, Dept Mat & Environm Chem, Svante Arrhenius Väg 16C, SE-10691 Stockholm, Sweden..ORCID-id: 0000-0003-2666-0704
Lipidor AB, Svardvagen 13, SE-18233 Danderyd, Sweden.;Stockholm Univ, Dept Mat & Environm Chem, Svante Arrhenius Väg 16C, SE-10691 Stockholm, Sweden..
Malmö universitet, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV). CR Competence AB, Naturvetarvägen 14, Lund, SE-223 62, Sweden.
Lipidor AB, Svardvagen 13, SE-18233 Danderyd, Sweden..
Visa övriga samt affilieringar
2022 (Engelska)Ingår i: Pharmaceutics, ISSN 1999-4923, E-ISSN 1999-4923, Vol. 14, nr 4, artikel-id 794Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

A novel formulation technology called AKVANO (R) has been developed with the aim to provide a tuneable and versatile drug delivery system for topical administration. The vehicle is based on a water-free lipid formulation where selected lipids, mainly phospholipids rich in phosphatidylcholine, are dissolved in a volatile solvent, such as ethanol. With the aim of describing the basic properties of the system, the following physicochemical methods were used: viscometry, dynamic light scattering, NMR diffusometry, and atomic force microscopy. AKVANO formulations are non-viscous, with virtually no or very minute aggregates formed, and when applied to the skin, e.g., by spraying, a thin film consisting of lipid bilayer structures is formed. Standardized in vitro microbiological and irritation tests show that AKVANO formulations meet criteria for antibacterial, antifungal, and antiviral activities and, at the same time, are being investigated as a non-irritant to the skin and eye. The ethanol content in AKVANO facilitates incorporation of many active pharmaceutical ingredients (>80 successfully tested) and the phospholipids seem to act as a solubilizer in the formulation. In vitro skin permeation experiments using Strat-M (R) membranes have shown that AKVANO formulations can be designed to alter the penetration of active ingredients by changing the lipid composition.

Ort, förlag, år, upplaga, sidor
MDPI , 2022. Vol. 14, nr 4, artikel-id 794
Nyckelord [en]
topical drug delivery, phospholipids, physicochemical methods, atomic force microscopy, antibacterial, antiviral, antifungal, in vitro skin irritation, in vitro eye irritation, in vitro skin permeation
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:mau:diva-51750DOI: 10.3390/pharmaceutics14040794ISI: 000786952500001PubMedID: 35456628Scopus ID: 2-s2.0-85128485764OAI: oai:DiVA.org:mau-51750DiVA, id: diva2:1661983
Tillgänglig från: 2022-05-30 Skapad: 2022-05-30 Senast uppdaterad: 2024-06-18Bibliografiskt granskad

Open Access i DiVA

fulltext(4108 kB)419 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 4108 kBChecksumma SHA-512
c8ccabb75592740661f062c9a34e90ff4832ad0540c6a2f097592ba20984550df9ac3fc350a52775df49b2c69a4614f7581ec7b8af30f255b2939ae977eb8363
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMedScopus

Sök vidare i DiVA

Av författaren/redaktören
Holmbäck, Jan
Av organisationen
Institutionen för biomedicinsk vetenskap (BMV)
I samma tidskrift
Pharmaceutics
Medicin och hälsovetenskap

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 421 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 70 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf