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Glucose-to-Resistor Transduction Integrated into a Radio-Frequency Antenna for Chip-less and Battery-less Wireless Sensing
Malmö universitet, Biofilms Research Center for Biointerfaces. Malmö universitet, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV). Department of Biomedical Science, Faculty of Health and Society, Malmö University, Malmö 205 06, Sweden;Biofilms−Research Center for Biointerfaces, Malmö University, Malmö 205 06, Sweden.
State Research Institute, Centre for Physical Sciences and Technology, Saulėtekio av. 3, Vilnius LT-10257, Lithuania.
Institute of Biochemistry, Life Sciences Centre, Vilnius University, Saulėtekio al. 7, Vilnius LT-10223, Lithuania;Faculty of Fundamental Sciences, Vilnius Gediminas Technical University, Saulėtekio al. 11, Vilnius LT-10223, Lithuania.ORCID-id: 0000-0003-3938-3574
Institute of Biochemistry, Life Sciences Centre, Vilnius University, Saulėtekio al. 7, Vilnius LT-10223, Lithuania.
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2022 (Engelska)Ingår i: ACS Sensors, E-ISSN 2379-3694, Vol. 7, nr 4, s. 1222-1234Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

To maximize the potential of 5G infrastructure in healthcare, simple integration of biosensors with wireless tag antennas would be beneficial. This work introduces novel glucose-to-resistor transduction, which enables simple, wireless biosensor design. The biosensor was realized on a near-field communication tag antenna, where a sensing bioanode generated electrical current and electroreduced a nonconducting antenna material into an excellent conductor. For this, a part of the antenna was replaced by a Ag nanoparticle layer oxidized to high-resistance AgCl. The bioanode was based on Au nanoparticle-wired glucose dehydrogenase (GDH). The exposure of the cathode-bioanode to glucose solution resulted in GDH-catalyzed oxidation of glucose at the bioanode with a concomitant reduction of AgCl to highly conducting Ag on the cathode. The AgCl-to-Ag conversion strongly affected the impedance of the antenna circuit, allowing wireless detection of glucose. Mimicking the final application, the proposed wireless biosensor was ultimately evaluated through the measurement of glucose in whole blood, showing good agreement with the values obtained with a commercially available glucometer. This work, for the first time, demonstrates that making a part of the antenna from the AgCl layer allows achieving simple, chip-less, and battery-less wireless sensing of enzyme-catalyzed reduction reaction. 

Ort, förlag, år, upplaga, sidor
American Chemical Society (ACS), 2022. Vol. 7, nr 4, s. 1222-1234
Nyckelord [en]
Internet of Things, wireless detection of glucose, direct electron transfer, glucose dehydrogenase, chip-less wireless sensing
Nationell ämneskategori
Analytisk kemi
Identifikatorer
URN: urn:nbn:se:mau:diva-51019DOI: 10.1021/acssensors.2c00394ISI: 000794994500032PubMedID: 35392657Scopus ID: 2-s2.0-85128799436OAI: oai:DiVA.org:mau-51019DiVA, id: diva2:1650841
Forskningsfinansiär
Vetenskapsrådet, 2018-04320KK-stiftelsen, 20170058KK-stiftelsen, 20190010Tillgänglig från: 2022-04-08 Skapad: 2022-04-08 Senast uppdaterad: 2024-03-05Bibliografiskt granskad
Ingår i avhandling
1. Development of Wireless Biosensors Integrated into the Radio Frequency Antenna for Chipless and Battery-less Monitoring of Biological Reactions
Öppna denna publikation i ny flik eller fönster >>Development of Wireless Biosensors Integrated into the Radio Frequency Antenna for Chipless and Battery-less Monitoring of Biological Reactions
2023 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Development of wireless sensors and biosensors is currently experiencing a rapid progress with a substantial focus directed toward highlighting their potential applications as non-invasive wearables, implants, and highly mobile point-of-care devices. Integration of wireless biosensors into the Internet of Things (IoT) is widely acknowledged as a technological advancement with the potential to significantly change daily life. To maximize this potential, simple integration of biosensors with wireless communication elements would be advantageous. In this regard, systems functioning in chipless, and battery-less modes outperform integrated circuit (IC) based and battery-powered wireless biosensors. Nevertheless, the accessibility of these wireless designs is still limited. In this study, we present a novel approach where incorporating silver nanoparticles(AgNPs) as a part of the radio frequency (RF) tag antenna enables the realization of simple, chipless, and battery-less wireless sensing of biological oxidation and reduction reactions. We exemplified the mechanism of operation in such systems by electronic wiring of enzymes through direct electron transfer (DET) and microorganisms through mediated electron transfer (MET) to the redox conversion of Ag/AgCl. The wiring was designed to facilitate the transformation of metallic AgNPs into AgCl (Ag → AgCl) or the conversion of AgCl particles back into metallic AgNPs (AgCl → Ag) when the enzymatic/microorganism based electron transfer reactions were present. These reactions occurring on the biosensor RF tag antenna strongly changed the impedance of the tag, which was wirelessly monitored by a radio frequency identification (RFID) reader. The functionality of the proposed setup in direct electron transfer coupling of the enzymatic reactions to the redox conversion of the Ag/AgCl was demonstrated by wireless detection of glucose in whole blood samples and hydrogen peroxide penetrated through the skin membrane using the enzymes glucose dehydrogenase(GDH) and horseradish peroxidase (HRP). Additionally, the capability of the proposed configuration in mediated electron transfer wiring of microorganisms to the Ag/AgCl electrochemistry was shown by wireless monitoring of medically relevant microbial biofilms in simulated wound fluid. Generalizing, the results of this work, for the first time, demonstrated that exploiting Ag/AgCl as a part of the tag antenna allows simple, chipless, and battery-less wireless sensing of biological oxidation and reduction reactions.

Ort, förlag, år, upplaga, sidor
Malmö: Malmö University Press, 2023. s. 108
Serie
Malmö University Health and Society Dissertations, ISSN 1653-5383 ; 99
Nationell ämneskategori
Kemi Teknik och teknologier Medicinsk bioteknologi
Identifikatorer
urn:nbn:se:mau:diva-63289 (URN)10.24834/isbn.9789178774128 (DOI)9789178774111 (ISBN)9789178774128 (ISBN)
Disputation
2023-10-27, AS: E002, Faculty of Health and Society, 09:15
Opponent
Handledare
Anmärkning

Paper IV in dissertation as manuscript.

Tillgänglig från: 2023-10-31 Skapad: 2023-10-30 Senast uppdaterad: 2024-02-27Bibliografiskt granskad

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Shafaat, AtefehGonzalez-Martinez, Juan FranciscoNeilands, JessicaBjörklund, SebastianSotres, JavierRuzgas, Tautgirdas

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Shafaat, AtefehRatautas, DaliusGonzalez-Martinez, Juan FranciscoNeilands, JessicaBjörklund, SebastianSotres, JavierRuzgas, Tautgirdas
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