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Physical Inactivity Is Associated With Post-discharge Mortality and Re-hospitalization Risk Among Swedish Heart Failure Patients-The HARVEST-Malmö Study
Lund Univ, Dept Clin Sci, Malmo, Sweden..
Lund Univ, Dept Clin Sci, Malmo, Sweden.;Lund Univ, Skane Univ Hosp, Dept Cardiol, Malmo, Sweden..
Lund Univ, Dept Clin Sci, Malmo, Sweden.;Lund Univ, Skane Univ Hosp, Dept Internal Med, Malmo, Sweden..
Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Malmö University, Biofilms Research Center for Biointerfaces. Lund Univ, Dept Clin Sci, Malmo, Sweden..
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2022 (English)In: Frontiers in Cardiovascular Medicine, E-ISSN 2297-055X, Vol. 9, article id 843029Article in journal (Refereed) Published
Abstract [en]

BackgroundSeveral studies have examined the role of physical activity as a predictor of heart failure (HF) mortality and morbidity. Here, we aimed to evaluate the role of self-reported physical activity as an independent risk factor of post-discharge mortality and re-hospitalization in patients hospitalized for HF, as well as study the association between physical activity and 92 plasma proteins associated with cardiovascular disease (CVD). MethodsFour-hundred-and-thirty-four patients hospitalized for HF (mean age 75 years; 32% women) were screened for physical activity derived from questionnaires in the Swedish national public health survey. The median follow-up time to death and re-hospitalization was 835 (interquartile range, 390-1,432) and 157 (43-583) days, respectively. Associations between baseline reported physical activity, mortality and re-hospitalization risk were analyzed using multivariable Cox regression analysis. Plasma samples from 295 study participants were analyzed with a proximity extension assay consisting of 92 proteins. Associations between proteins and physical activity were explored using a false discovery rate of <5%, and significant associations were taken forward to multivariate analyses. ResultsIn the multivariate Cox regression model, physical inactivity, defined as physical activity time <1 h throughout the week was associated with increased risk of all-cause mortality (HR 1.71; CI95% 1.26-2.31; p = 5.9 x 10(-4)) as well as all-cause re-hospitalization (HR 1.27; CI95% 1.01-1.60; p = 0.038). Further, physical inactivity was associated with elevated plasma levels of Metalloproteinase inhibitor 4, Soluble interleukin 1 receptor-like 1, Elafin and Transferrin receptor protein 1, which are implicated in myocardial fibrosis, migration and apoptosis. ConclusionsSelf-reported low weekly physical activity is associated with increased risk of mortality and re-hospitalization in patients hospitalized for HF independent of traditional risk factors. Furthermore, physical inactivity was associated with elevated levels of 4 proteins linked to cardiovascular disease.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2022. Vol. 9, article id 843029
Keywords [en]
heart failure, cardiac rehabilitation, biomarkers, physical activity, risk factor
National Category
Cardiac and Cardiovascular Systems
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URN: urn:nbn:se:mau:diva-50938DOI: 10.3389/fcvm.2022.843029ISI: 000769781000001PubMedID: 35265689Scopus ID: 2-s2.0-85138508591OAI: oai:DiVA.org:mau-50938DiVA, id: diva2:1649903
Available from: 2022-04-05 Created: 2022-04-05 Last updated: 2024-02-05Bibliographically approved

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Dieden, Anna

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