Malmö University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
A novel versatile flow-donor chamber as biorelevant ex-vivo test assessing oral mucoadhesive formulations
Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Malmö University, Biofilms Research Center for Biointerfaces.
Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Malmö University, Biofilms Research Center for Biointerfaces.ORCID iD: 0000-0001-6254-8539
Nanologica AB; KTH, Royal Institute of Technology.
CTC Clinical Trial Consultants AB.
Show others and affiliations
2021 (English)In: European Journal of Pharmaceutical Sciences, ISSN 0928-0987, E-ISSN 1879-0720, Vol. 166, article id 105983Article in journal (Refereed) Published
Abstract [en]

Oral transmucosal drug delivery is a non-invasive administration route for rapid therapeutic onset and greater bioavailability avoiding the first-pass metabolism. Mucoadhesive formulations are advantageous as they may retain the drug at the administration site. Proper equipment to assess mucoadhesive properties and corresponding drug absorption is fundamental for the development of novel drug delivery systems. Here we developed a new flow-through donor chamber for well-established diffusion cells, and we tested the effects on drug and formulation retention in situ of adding mucoadhesive polymers or mesoporous silica particles to a reference formulation. Mesoporous silica particles are of particular interest as they may be used to encapsulate and retain drug molecules. Compared to other ex-vivo methods described in literature for assessing mucoadhesive performance and transmucosal drug delivery, this new donor chamber provides several advantages: i) it reflects physiological conditions better as a realistic saliva flow can be provided over the administration site, ii) it is versatile since it can be mounted on any kind of vertical diffusion cell allowing simultaneous detection of drug retention at the administration site and drug permeation through the tissue, and iii) it enables optical quantification of formulations residence time aided by image processing. This new flow-through donor diffusion cell set-up proved sensitive to differentiate a reference formulation from one where 20 %(w/w) Carbomer was added (to further improve the mucoadhesive properties), with respect to both drug and formulation residence times. We also found that mesoporous silica particles, investigated as particles only and mixed together with the reference formulation, gave very similar drug and formulation retention to what we observed with the mucoadhesive Carbomer. However, after some time (>30 min) it became obvious that the tablet excipients in the reference formulation promote particle retention on the mucosa. This work provides a new simple and versatile biorelevant test for the evaluation of oral mucoadhesive formulations and paves the way for further studies on mesoporous silica particles as valuable excipients for enhancing oral mucoadhesion.

Place, publisher, year, edition, pages
Elsevier, 2021. Vol. 166, article id 105983
Keywords [en]
Ex-vivo release-permeation systems, Flow through diffusion cells, Intraoral drug delivery, Mesoporous silica particles, Mucoadhesion, Oral transmucosal delivery
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:mau:diva-45899DOI: 10.1016/j.ejps.2021.105983ISI: 000704269600004PubMedID: 34461276Scopus ID: 2-s2.0-85114373054OAI: oai:DiVA.org:mau-45899DiVA, id: diva2:1594334
Available from: 2021-09-15 Created: 2021-09-15 Last updated: 2024-02-05Bibliographically approved

Open Access in DiVA

fulltext(2324 kB)212 downloads
File information
File name FULLTEXT01.pdfFile size 2324 kBChecksum SHA-512
382efdf39e125aa081c3fe86d3bee5d218b6e6e779124d99a626224f0b319d6b563deed5974d08845b7b97ba098cd95fa8dc053c07686d6003e92f724339677c
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Gidvall, SannaBjörklund, SebastianEngblom, JohanValetti, Sabrina

Search in DiVA

By author/editor
Gidvall, SannaBjörklund, SebastianEngblom, JohanValetti, Sabrina
By organisation
Department of Biomedical Science (BMV)Biofilms Research Center for Biointerfaces
In the same journal
European Journal of Pharmaceutical Sciences
Pharmaceutical Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 212 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 177 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf