Publikationer från Malmö universitet
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Effects of ethylene oxide chain length on crystallization of polysorbate 80 and its related compounds
Malmö universitet, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV). Malmö universitet, Biofilms Research Center for Biointerfaces.
Malmö universitet, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV). Malmö universitet, Biofilms Research Center for Biointerfaces.ORCID-id: 0000-0001-5654-4339
LONZA AG, Switzerland.
LONZA AG, Switzerland.
Vise andre og tillknytning
2021 (engelsk)Inngår i: Journal of Colloid and Interface Science, ISSN 0021-9797, E-ISSN 1095-7103, Vol. 592, s. 468-484, artikkel-id S0021-9797(21)00078-3Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

As a result of the synthesis protocol polyoxyethylene sorbitan monooleate (polysorbate 80, PS80) is a highly complex mixture of compounds. PS80 was therefore separated into its main constituents, e.g. polyoxyethylene isosorbide esters and polyoxyethylene esters, as well as mono- di- and polyesters using preparative high-performance liquid chromatography. In this comprehensive study the individual components and their ethoxylation level were verified by matrix assisted laser desorption/ionization time-of-flight and their thermotropic behavior was analyzed using differential scanning calorimetry and X-ray diffraction. A distinct correlation was found between the average length of the ethylene oxide (EO) chains in the headgroup and the individual compounds' ability to crystallize. Importantly, a critical number of EO units required for crystallization of the headgroup was determined (6 EO units per chain or 24 per molecule). The investigation also revealed that the hydrocarbon tails only crystallize for polyoxyethylene sorbitan esters if saturated. PS80 is synthesized by reacting with approximately 20 mol of EO per mole of sorbitol, however, the number of EO units in the sorbitan ester in commercial PS80 products is higher than the expected 20 (5 EO units per chain). The complex behavior of all tested compounds revealed that if the amount of several of the linear by-products is reduced, the number of EO units in the chains will stay below the critical number and the product will not be able to crystallize by the EO chains.

sted, utgiver, år, opplag, sider
Elsevier, 2021. Vol. 592, s. 468-484, artikkel-id S0021-9797(21)00078-3
Emneord [en]
Crystallization, Differential scanning calorimetry, Ethylene oxide chains, Liquid chromatography, Polysorbate 80, Thermotropic behavior
HSV kategori
Identifikatorer
URN: urn:nbn:se:mau:diva-41655DOI: 10.1016/j.jcis.2021.01.065ISI: 000634152600006PubMedID: 33711648Scopus ID: 2-s2.0-85102147545OAI: oai:DiVA.org:mau-41655DiVA, id: diva2:1542596
Tilgjengelig fra: 2021-04-08 Laget: 2021-04-08 Sist oppdatert: 2024-02-05bibliografisk kontrollert

Open Access i DiVA

fulltext(3902 kB)229 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 3902 kBChecksum SHA-512
56642b73faeb27cc117775ab3ba7e47b079eae92530e016edbbea8c82a3252602fbc6d270705e56cec7394ee5904e250640bc5ca0fa50975b07e16cbde001a4d
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMedScopus

Person

Lind, Tania K.Nilsson, Emelie J.Skansberger, TatyanaMorin, MaximKocherbitov, VitalyEngblom, Johan

Søk i DiVA

Av forfatter/redaktør
Lind, Tania K.Nilsson, Emelie J.Skansberger, TatyanaMorin, MaximKocherbitov, VitalyEngblom, Johan
Av organisasjonen
I samme tidsskrift
Journal of Colloid and Interface Science

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 231 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 166 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf