Malmö University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Effect of Avocado/Soybean Unsaponifiables on Osseointegration: A Proof-of-Principle Preclinical In Vivo Study
Malmö högskola, Faculty of Odontology (OD).ORCID iD: 0000-0001-8161-3754
Show others and affiliations
2014 (English)In: International Journal of Oral & Maxillofacial Implants, ISSN 0882-2786, E-ISSN 1942-4434, Vol. 29, no 4, p. 949-957Article in journal (Refereed) Published
Abstract [en]

Purpose: To evaluate the influence of administration of avocado/soybean unsaponifiables (ASU) on implant osseointegration in rat tibiae. Materials and Methods: Thirty rats were randomly assigned into one of three equal-sized groups: (1) ASU1: administration of ASU starting 7 days prior to implant placement; (2) ASU2: administration of ASU starting on the day of implant placement, and (3) CTL: administration of saline solution. In all animals, one titanium implant was placed in each tibia. All animals received ASU or saline solution by gavage daily until sacrifice 60 days postoperatively. Implant osseointegration and bone maturation were assessed by biomechanical and radiographic bone density analysis; descriptive histology; immunohistochemistry for bone morphogenetic protein 2 (BMP-2), transforming growth factor beta 1 (TGF-beta 1), and osteocalcin; and histomorphometric evaluation of bone-to-implant contact (BIC) and mineralized bone area fraction within the threads of the implant. Results: ASU1 and ASU2 showed three times higher expression of BMP-2 and nine times higher expression of TGF-beta compared with CTL (P < .05). Histomorphometric analysis, however, showed that both ASU1 and ASU2 groups presented significantly higher BIC values only in the cortical bone compartment when compared to CTL (P < .05). Conclusion: ASU consumption seems to exert only a subtle effect on implant osseointegration.

Place, publisher, year, edition, pages
Quintessence , 2014. Vol. 29, no 4, p. 949-957
Keywords [en]
animal study, avocado/soybean unsaponifiables, histomorphometry, implant osseointegration
National Category
Dentistry
Identifiers
URN: urn:nbn:se:mau:diva-39267DOI: 10.11607/jomi.3498ISI: 000346119800022PubMedID: 25032777Scopus ID: 2-s2.0-84918546123Local ID: 17624OAI: oai:DiVA.org:mau-39267DiVA, id: diva2:1519137
Available from: 2021-01-18 Created: 2021-01-18 Last updated: 2024-02-05Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records

Stavropoulos, Andreas

Search in DiVA

By author/editor
Pimentel Lopes de Oliveira, Guilherme JoseSpin-Neto, RubensStavropoulos, AndreasSpolidorio, Luis CarlosMarcantonio, Elcio, Jr.Chierici Marcantonio, Rosemary Adriana
By organisation
Faculty of Odontology (OD)
In the same journal
International Journal of Oral & Maxillofacial Implants
Dentistry

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 39 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf