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Bacterial profiles and proteolytic activity in peri-implantitis versus healthy sitesBacterial profiles and proteolytic activity in peri-implantitis versus healthy sites
Malmö högskola, Odontologiska fakulteten (OD).
Malmö högskola, Odontologiska fakulteten (OD).ORCID-id: 0000-0002-8183-8846
Malmö högskola, Odontologiska fakulteten (OD).
Malmö högskola, Odontologiska fakulteten (OD).ORCID-id: 0000-0001-5888-664X
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2015 (Engelska)Ingår i: Anaerobe, ISSN 1075-9964, E-ISSN 1095-8274, Vol. 35, s. 28-34Artikel i tidskrift (Refereegranskat)
Abstract [en]

Peri-implantitis is a biofilm-induced destructive inflammatory process that, over time, results in loss of supporting bone around an osseointegrated dental implant. Biofilms at peri-implantitis sites have been reported to be dominated by Gram-negative anaerobic rods with a proteolytic metabolism such as, Fusobacterium, Porphyromonas, Prevotella and Tannerella, as well as anaerobic Gram-positive cocci. In this study, we hypothesized that protease activity is instrumental in driving bone destruction and we therefore compared the microbial composition and level of protease activity in samples of peri-implant biofluid (PIBF) from 25 healthy subjects (H group) and 25 subjects with peri-implantitis (PI group). Microbial composition was investigated using culture techniques and protease activity was determined using a FITC-labelled casein substrate. The microbial composition was highly variable in subjects both in the H and PI groups but one prominent difference was the prevalence of Porphyromonas/Prevotella and anaerobic Gram positive cocci which was significantly higher in the PI than in the H group. A subgroup of subjects with peri-implantitis displayed a high level of protease activity in the PIBF compared to healthy subjects. However, this activity could not be related to the presence of specific bacterial species. We propose that a high level of protease activity may be a predictive factor for disease progression in peri-implantitis. Further longitudinal studies are however required to determine whether assessment of protease activity could serve as a useful method to identify patients at risk for progressive tissue destruction.

Ort, förlag, år, upplaga, sidor
Academic Press, 2015. Vol. 35, s. 28-34
Nyckelord [en]
Biofilm, oral bacteria, oral cavity, oral implant, bacteria
Nationell ämneskategori
Naturvetenskap
Identifikatorer
URN: urn:nbn:se:mau:diva-15477DOI: 10.1016/j.anaerobe.2015.04.004ISI: 000364247300006PubMedID: 25870134Scopus ID: 2-s2.0-84939568102Lokalt ID: 19811OAI: oai:DiVA.org:mau-15477DiVA, id: diva2:1418998
Tillgänglig från: 2020-03-30 Skapad: 2020-03-30 Senast uppdaterad: 2024-02-05Bibliografiskt granskad

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Neilands, JessicaWickström, ClaesKinnby, BertilDavies, Julia RFriberg, BertilSvensäter, Gunnel

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Neilands, JessicaWickström, ClaesKinnby, BertilDavies, Julia RFriberg, BertilSvensäter, Gunnel
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