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Transferrin receptor in children and its correlation with iron status and types of milk consumption
Malmö högskola, Faculty of Health and Society (HS), Department of Care Science (VV).ORCID iD: 0000-0002-9679-0654
2003 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 92, no 6, p. 671-675Article in journal (Refereed)
Abstract [sv]

Syfte: Denna studie jämförde koncentrationen av transferrin receptor (TfR) med järnstatus parametrar i relation till barnets intag av komjölk och välling. Metod: TfR, β-Haemoglobin, serum ferritin och medelcellsvolumen (MCV) på de röda blodkropparna analyserades i en population av 263 barn i åldern 2.5 år. Mängden komjölk och välling som barnet drack registrerades. Resultat: Det fanns en signifikant skillnad i TfR/log. ferritin mellan barn vars intag av komjölk var < 500 ml respektive barn med intag av mjölk > 500 ml (p= 0.003). Där fanns ett signifikant högre värde av TfR/log. ferritin bland barn med en medelscellsvolum av de röda blodkropparna på < 75fL jämfört med de som hade > 75fL (p=<0.0001). Koncentrationen av TfR var signifikant högre efter järnbehandling. Konklusion: Högre koncentrationer av TfR var korrelerade med lägre koncentrationer av haemoglobin och MCV av röda bloda kroppar. Mjölk konsumtion ökade risken för högre kvot av TfR/log ferritin. TfR koncentrationen var signifikant lägre efter järnbehandling.

Abstract [en]

Aim: This study compared transferrin receptor (TfR) concentrations with iron parameters relative to a child´s intake of cow´s milk and follow-on formula. Methods: TfR, β-Haemoglobin, serum ferritin and mean corpuscular volume (MCV) of red blood cells were analyzed in a study population of 263 children aged 2.5 y. The amount of cow´s milk and follow-on formula consumed were recorded. Results: There was a significant difference of TfR/log. ferritin between children whose milk intake was < 500 ml and those with a milk intake of > 500 ml (p=0.003). There were significantly higher values of TfR/log. ferritin in children whose MCV of red blood cells was < 75fL than those with > 75fL (p=<0.0001). The TfR concentrations were significantly lower after iron treatment. Conclusion: Higher concentrations of TfR were correlated with lower concentrations of haemoglobin and MCV of red blood cells. Milk consumption increases the risk of higher ratio of TfR/log. ferritin. TfR concentrations were significantly lower after iron treatment.

Place, publisher, year, edition, pages
Taylor & Francis, 2003. Vol. 92, no 6, p. 671-675
Keywords [en]
children, cow´s milk, iron, transferrin receptor
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:mau:diva-15148DOI: 10.1111/j.1651-2227.2003.tb00597.xLocal ID: 14862OAI: oai:DiVA.org:mau-15148DiVA, id: diva2:1418669
Available from: 2020-03-30 Created: 2020-03-30 Last updated: 2022-06-27Bibliographically approved

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Bramhagen, Ann-Cathrine

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