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Phytosphingosine Prevents the Formation of Young Salivary Biofilms in vitro
Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), Free University of Amsterdam and University of Amsterdam, Amsterdam, The Netherlands.
Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), Free University of Amsterdam, University of Amsterdam, Amsterdam, Netherlands.
Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), Free University of Amsterdam, University of Amsterdam, Gustav Mahlerlaan 3004, Amsterdam, NL-1081 LA, Netherlands; Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), Free University of Amsterdam, University of Amsterdam, Amsterdam, Netherlands.
Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), Free University of Amsterdam, University of Amsterdam, Gustav Mahlerlaan 3004, Amsterdam, NL-1081 LA, Netherlands.
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2018 (Engelska)Ingår i: Caries Research, ISSN 0008-6568, E-ISSN 1421-976X, Vol. 52, nr 1-2, s. 7-13Artikel i tidskrift (Refereegranskat)
Abstract [en]

Dental biofilms are formed in a multistep process that is initiated by the adhesion of oral bacteria to the dental hard surface. As dental biofilms are associated with oral diseases their control is necessary in order to maintain oral health. Recently, it was revealed that phytosphingosine (PHS)-treated hydroxyapatite discs showed anti-adhesive activity in a static in vitro biofilm model against Streptococcus mutans. The goal of the present study was to further unravel the anti-adhesive and anti-biofilm properties of PHS in both static and dynamic in vitro biofilm models against a full salivary inoculum. After 3 h under static conditions, bacterial adherence on PHS-treated cover glass slides was reduced by 60% compared to the untreated surface. After 6 and 24 h under static conditions, no significant differences in bacterial adherence were observed between PHS-treated and untreated cover glass slides. However, under dynamic conditions, i.e., the presence of shear forces, virtually no bacterial adherence was observed for up to 16 h on PHS-coated surfaces. Besides, PHS showed a strong bactericidal activity on salivary biofilms. Treatment of a 3- and 6-h statically grown biofilm resulted in a 99 and 94% reduction of viable cells, respectively, which was effectuated within minutes. In principle, these anti-adherence and anti-biofilm properties make PHS a promising candidate ingredient for use in oral care products aimed at oral microbial control. (C) 2017 S. Karger AG, Basel

Ort, förlag, år, upplaga, sidor
S. Karger, 2018. Vol. 52, nr 1-2, s. 7-13
Nyckelord [en]
Anti-adherence properties, Anti-biofilm properties, Phytosphingosine, Prevention, Saliva
Nationell ämneskategori
Odontologi
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URN: urn:nbn:se:mau:diva-5917DOI: 10.1159/000480712ISI: 000426035300003PubMedID: 29232659Scopus ID: 2-s2.0-85038084155Lokalt ID: 26841OAI: oai:DiVA.org:mau-5917DiVA, id: diva2:1402803
Tillgänglig från: 2020-02-28 Skapad: 2020-02-28 Senast uppdaterad: 2024-06-17Bibliografiskt granskad

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