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Impact of molecular linker size on physicochemical properties of assembled gold nanoparticle mono-/multi-layers and their applicability for functional binding of biomolecules
Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Malmö University, Biofilms Research Center for Biointerfaces. School of Civil and Environmental Engineering, Nanyang Technological University, 50 Nanyang Ave, 639798 Singapore, Singapore; Residues and Resource Reclamation Centre (R3C), Nanyang Environment and Water Research Institute (NEWRI), Nanyang Technological University, CleanTech One, 637141Singapore, Singapore.
Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Malmö University, Biofilms Research Center for Biointerfaces.
Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Malmö University, Biofilms Research Center for Biointerfaces. Division of Solid State Physics, NanoLund, Lund University, 221 00 Lund, Sweden.
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2019 (English)In: Journal of Colloid and Interface Science, ISSN 0021-9797, E-ISSN 1095-7103, Vol. 543, p. 307-316Article in journal (Refereed) Published
Abstract [en]

In this work the impact of molecular inter-linker size on gold nanoparticle (AuNP) mono-/multilayer structural properties, density and homogeneity has been investigated. These characteristics are of great importance for functional binding of biomolecules. Positively charged high or low molecular weight inter-linkers, poly-L-lysine (PLL) or N-(6-mercapto)hexylpyridinium (MHP), were used to attach negatively charged AuNPs on a planar gold surface as well as to further interlink into a multilayer structure via layer-by-layer deposition. The inter-particle interaction within the assembled AuNP films was adjusted by the ionic strength in the AuNPs dispersions The AuNP layer density and structural/viscoelastic properties were evaluated by the quartz crystal microbalance with dissipation (QCM-D) technique. The validity of the commercial Voigt model, specifically developed for quantitative QCM-D data analysis of homogeneous viscoelastic films, was evaluated by a model independent analysis when comparing the assembled AuNP films with a homogeneous layer of a mucin from bovine submaxillary glands. Both AuNP mono- and multilayers, attached/interlinked via long flexible PLL molecules assembled to denser and more soft/viscous structures compared to those interlinked by short MHP compounds. Thus, PLL-interlinked AuNP mono-/multilayer structures were further investigated as a platform for laccase enzyme functional adsorption via qualitative assessment of bioelectrochemical characteristics of the enzyme. (C) 2019 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
Elsevier, 2019. Vol. 543, p. 307-316
Keywords [en]
Poly-L-lysine, N-(6-mercaptohexyl)pyridinium, Gold nanoparticles, Layer-by-layer deposition, Biomolecule adsorption, Bio-electro-catalysis, Electrochemical-quartz crystal, microbalance with dissipation
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Natural Sciences
Identifiers
URN: urn:nbn:se:mau:diva-4428DOI: 10.1016/j.jcis.2019.02.048ISI: 000462416900033PubMedID: 30825679Scopus ID: 2-s2.0-85062011660Local ID: 30190OAI: oai:DiVA.org:mau-4428DiVA, id: diva2:1401259
Available from: 2020-02-28 Created: 2020-02-28 Last updated: 2024-03-27Bibliographically approved

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Arnebrant, ThomasRuzgas, Tautgirdas

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