The societal effects of forced migration are a burning topic of current political debate in Europe. There is an obvious absence of sustainable approaches to deal with this issue. We describe a collaborative and systemic regional effort, involving some 50 partners, towards a health-promoting and inclusive integration process designed to reach all refugees who settle in the southern region of Sweden. The main components of this process are now being disseminated to other regions in Sweden, which is contributing to national capacity-building. In addition, a national educational programme is being developed for those engaged in conveying civic and health information to asylum seekers and refugees. This work involves stakeholders in collaboration with six universities from different geographical areas of Sweden. The effort we describe in this report is expected to greatly contribute to providing better opportunities for all refugees in Sweden, and to empower them to control their own adaptation to a new life, thus reducing the risk of health deterioration often seen among them.