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Bone Immune Response to Materials, Part II: Copper and Polyetheretherketone (PEEK) Compared to Titanium at 10 and 28 Days in Rabbit Tibia
Department of Prosthodontics, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.ORCID-id: 0000-0003-1624-6702
Malmö universitet, Odontologiska fakulteten (OD). Malmö universitet, Biofilms Research Center for Biointerfaces.
Malmö universitet, Odontologiska fakulteten (OD). Malmö universitet, Biofilms Research Center for Biointerfaces.ORCID-id: 0000-0001-7488-3588
Malmö universitet, Odontologiska fakulteten (OD). Malmö universitet, Biofilms Research Center for Biointerfaces.
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2019 (Engelska)Ingår i: Journal of Clinical Medicine, E-ISSN 2077-0383, Vol. 8, nr 6, artikel-id 814Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Abstract: Osseointegration is likely the result of an immunologically driven bone reaction to materials such as titanium. Osseointegration has resulted in the clinical possibility to anchor oral implants in jaw bone tissue. However, the mechanisms behind bony anchorage are not fully understood and complications over a longer period of time have been reported. The current study aims at exploring possible differences between copper (Cu) and polyetheretherketone (PEEK) materials that do not osseointegrate, with osseointegrating cp titanium as control. The implants were placed in rabbit tibia and selected immune markers were evaluated at 10 and 28 days of follow-up. Cu and PEEK demonstrated at both time points a higher immune activation than cp titanium. Cu demonstrated distance osteogenesis due to a maintained proinflammatory environment over time, and PEEK failed to osseointegrate due to an immunologically defined preferential adipose tissue formation on its surface. The here presented results suggest the description of two different mechanisms for failed osseointegration, both of which are correlated to the immune system.

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MDPI, 2019. Vol. 8, nr 6, artikel-id 814
Nyckelord [en]
biomaterial, bone, osseointegration, immune, implant, healing, titanium, PEEK, Cu
Nationell ämneskategori
Odontologi
Identifikatorer
URN: urn:nbn:se:mau:diva-15822DOI: 10.3390/jcm8060814ISI: 000475349300058PubMedID: 31181635Scopus ID: 2-s2.0-85076136759Lokalt ID: 28805OAI: oai:DiVA.org:mau-15822DiVA, id: diva2:1419344
Tillgänglig från: 2020-03-30 Skapad: 2020-03-30 Senast uppdaterad: 2024-03-27Bibliografiskt granskad

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Trindade, RicardoAlbrektsson, TomasGalli, SilviaPrgomet, ZdenkaWennerberg, Ann

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