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Bacterial Biofilm Formation on Resorbing Magnesium Implants
Malmö högskola, Odontologiska fakulteten (OD). Malmö högskola, Biofilms Research Center for Biointerfaces.
Malmö högskola, Odontologiska fakulteten (OD). Malmö högskola, Biofilms Research Center for Biointerfaces.ORCID-id: 0000-0003-3173-7577
Malmö högskola, Odontologiska fakulteten (OD). Malmö högskola, Biofilms Research Center for Biointerfaces.
2015 (engelsk)Inngår i: Open Journal of Medical Microbiology, ISSN 2165-3372, Vol. 5, nr 1Artikkel i tidsskrift (Fagfellevurdert)
Abstract [en]

Background: Implant-associated infections are a result of bacterial adhesion to an implant surface and subsequent biofilm formation at the implantation site. This study compares different magnesium materials based on their ability to resist bacterial adhesion as well as further biofilm formation. Material and Methods: The surfaces of four magnesium-based materials (Mg2Ag, Mg10Gd, WE43 and 99.99% pure Mg) were characterized using atomic force microscope. In addition, the samples were tested for their ability to resist biofilm formation. Planktonic bacteria of either S. epidermidis or E. faecalis were allowed to adhere to the magnesium surfaces for two hour followed by rinsing and, for S. epidermidis, further incubation of 24, 72 and 168 h was carried out. Results: E. faecalis had a significantly stronger adhesion to all magnesium surfaces compared to S. epidermidis (p = 0.001). Biofilm growth of S. epidermidis was different on various magnesium materials: the amount of bacteria increased up to 72 h but interestingly a significant decrease was seen at 168 h on Mg2Ag and WE43 surfaces. For pure Mg and Mg10Gd the biofilm formation reached plateau at 72 h. Surface characteristics of resorbable magnesium materials were changing over time, and the surface was generally less rough at 168 h compared to earlier time points. No correlation was found between the surface topology and the amount of adherent bacteria. Conclusion: In early stages of biofilm adhesion, no differences between magnesium materials were observed. However, after 72 h Mg2Ag and WE43 had the best ability to suppress S. epidermidis’ biofilm formation. Also, bacterial adhesion to magnesium materials was not dependent on samples’ surface topology.

sted, utgiver, år, opplag, sider
Council of scientific & industrial research, 2015. Vol. 5, nr 1
Emneord [en]
Bacterial Biofilm, Magnesium, Surface Topology
HSV kategori
Identifikatorer
URN: urn:nbn:se:mau:diva-7104DOI: 10.4236/ojmm.2015.51001Lokal ID: 28588OAI: oai:DiVA.org:mau-7104DiVA, id: diva2:1404058
Tilgjengelig fra: 2020-02-28 Laget: 2020-02-28 Sist oppdatert: 2022-06-27bibliografisk kontrollert

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