Publikationer från Malmö universitet
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Time-resolved small-angle neutron scattering as a probe for the dynamics of lipid exchange between human lipoproteins and naturally derived membranes
Malmö universitet, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV).ORCID-id: 0000-0001-6547-5427
Malmö universitet, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV).
Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Singapore.
Dept. of Clinical Sciences, Lund University, Jan Waldenströms gata 35, CRC, Box 50332, 212 13, Malmö, Sweden.
Vise andre og tillknytning
2019 (engelsk)Inngår i: Scientific Reports, E-ISSN 2045-2322, Vol. 9, nr 1, artikkel-id 7591Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Atherosclerosis is the main killer in the western world. Today's clinical markers include the total level of cholesterol and high-/low-density lipoproteins, which often fails to accurately predict the disease. The relationship between the lipid exchange capacity and lipoprotein structure should explain the extent by which they release or accept lipid cargo and should relate to the risk for developing atherosclerosis. Here, small-angle neutron scattering and tailored deuteration have been used to follow the molecular lipid exchange between human lipoprotein particles and cellular membrane mimics made of natural, "neutron invisible" phosphatidylcholines. We show that lipid exchange occurs via two different processes that include lipid transfer via collision and upon direct particle tethering to the membrane, and that high-density lipoprotein excels at exchanging the human-like unsaturated phosphatidylcholine. By mapping the specific lipid content and level of glycation/oxidation, the mode of action of specific lipoproteins can now be deciphered. This information can prove important for the development of improved diagnostic tools and in the treatment of atherosclerosis.

sted, utgiver, år, opplag, sider
Nature Publishing Group, 2019. Vol. 9, nr 1, artikkel-id 7591
Emneord [en]
Multidisciplinary Sciences
HSV kategori
Identifikatorer
URN: urn:nbn:se:mau:diva-4549DOI: 10.1038/s41598-019-43713-6ISI: 000468281500021PubMedID: 31110185Scopus ID: 2-s2.0-85066021599Lokal ID: 30138OAI: oai:DiVA.org:mau-4549DiVA, id: diva2:1401381
Tilgjengelig fra: 2020-02-28 Laget: 2020-02-28 Sist oppdatert: 2023-08-31bibliografisk kontrollert

Open Access i DiVA

fulltekst(2690 kB)90 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 2690 kBChecksum SHA-512
9e2a2d47d1c68ce0206c55cc65d301aed2dda8f5d6005dc60cab5267a65a6ea1af9c92b13c648d296a44c5c7781456b1a79c4b01aacde9884cb833b26125c141
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMedScopus

Person

Maric, SelmaLind, Tania KjellerupArnebrant, ThomasCárdenas, Marité

Søk i DiVA

Av forfatter/redaktør
Maric, SelmaLind, Tania KjellerupArnebrant, ThomasCárdenas, Marité
Av organisasjonen
I samme tidsskrift
Scientific Reports

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 90 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 42 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf