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Projekttyp/Bidragsform
Projektbidrag
Titel [sv]
Regulation of Surface Protein - Presentation on Streptococcus gordonii
Titel [en]
Regulation of Surface Protein - Presentation on Streptococcus gordonii
Abstract [sv]

Projektbeskrivning

We have shown that interaction of the commensal oral bacterium Streptococcus gordonii with salivary mucins results in presentation of new adhesins on the bacterial surface that enhance mucin-binding, thus ensuring its persistence in the oral cavity. We are using proteomic and transcriptomic approaches to identify the mechanisms by which these bacteria “sense” their surroundings and transduce the signal intracellularly allowing them to adjust their expression of adhesins.

Finansiär: National Institute of Health

Abstract [en]

Project description

We have shown that interaction of the commensal oral bacterium Streptococcus gordonii with salivary mucins results in presentation of new adhesins on the bacterial surface that enhance mucin-binding, thus ensuring its persistence in the oral cavity. We are using proteomic and transcriptomic approaches to identify the mechanisms by which these bacteria “sense” their surroundings and transduce the signal intracellularly allowing them to adjust their expression of adhesins.

Financier: National Institute of Health

ProjektansvarigSvensäter, Gunnel
ProjektmedarbetareDavies, Julia R
ProjektmedarbetareWickström, Claes
ProjektmedarbetareHenriksson, Agnethe
ProjektmedarbetareHerzberg, Mark
Tidsperiod
2016-07-01 - 2020-06-30
Nationell ämneskategori
Odontologi
Identifikatorer
DiVA, id: project:2919

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