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Dimitrijevic Carlsson, AlexandraORCID iD iconorcid.org/0000-0002-2260-8442
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Publications (6 of 6) Show all publications
Dimitrijevic Carlsson, A., Wahlund, K., Kindgren, E., Frodlund, M. & Alstergren, P. (2024). Increase in stress contributes to impaired jaw function in juvenile idiopathic arthritis: a two-year prospective study. Pediatric Rheumatology, 22(1), Article ID 30.
Open this publication in new window or tab >>Increase in stress contributes to impaired jaw function in juvenile idiopathic arthritis: a two-year prospective study
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2024 (English)In: Pediatric Rheumatology, E-ISSN 1546-0096, Vol. 22, no 1, article id 30Article in journal (Refereed) Published
Abstract [en]

BackgroundStress in patients with Juvenile Idiopathic Arthritis (JIA) has been found to be associated with orofacial pain, psychological distress, jaw dysfunction and loss of daily activities in a cross-sectional study. The aim of this study was to investigate the relations between stress and change of stress over time versus changes in orofacial pain, psychosocial factors and jaw function over a two-year period in patients with JIA.MethodsThis is a two-year prospective follow-up study involving 40 JIA patients. At baseline (2015) the median age was 12 years and at two-year follow up (2018) 14 years. The JIA patients were examined clinically and with questionnaires at baseline and follow-up with the diagnostic criteria for temporomandibular disorders (DC/TMD) and completed the same set of DC/TMD questionnaires regarding orofacial pain symptoms and psychosocial factors.ResultsChange in stress was associated with change in catastrophizing, psychological distress as well as limitation in general function and jaw function.ConclusionsThis study emphasizes the importance of maintaining a low stress level in patients with JIA since an increase in stress level over a two-year period seems to impair jaw function as well as psychological distress and catastrophizing.

Place, publisher, year, edition, pages
BioMed Central (BMC), 2024
Keywords
Juvenile Idiopathic Arthritis, Orofacial pain, Psychological distress, Psychosocial, Stress, Temporomandibular joint disorders
National Category
Rheumatology and Autoimmunity Dentistry
Identifiers
urn:nbn:se:mau:diva-66380 (URN)10.1186/s12969-024-00966-4 (DOI)001173488700001 ()38409027 (PubMedID)2-s2.0-85186196644 (Scopus ID)
Funder
Medical Research Council of Southeast Sweden (FORSS), FORSS-748481Swedish Dental AssociationMalmö UniversityRegion Östergötland, FOU 2-15-14
Available from: 2024-03-19 Created: 2024-03-19 Last updated: 2024-06-17Bibliographically approved
Starkhammar Johansson, C., Dimitrijevic Carlsson, A., Wahlund, K. & Alstergren, P. (2024). Periodontal Health in Children with Juvenile idiopathic arthritis. European Journal of Paediatric Dentistry, 25, Article ID 1.
Open this publication in new window or tab >>Periodontal Health in Children with Juvenile idiopathic arthritis
2024 (English)In: European Journal of Paediatric Dentistry, ISSN 1591-996X, E-ISSN 2035-648X, Vol. 25, article id 1Article in journal (Refereed) Published
Abstract [en]

AIM: To investigate gingival inflammation and prevalence of four specific periodontal associated pathogens in Juvenile idiopathic arthritis (JIA) in relation to orofacial pain, jaw function and systemic inflammatory activity in JIA.

METHODS: Forty-five children with JIA and 16 healthy children as controls, were enrolled. Subjects were examined and classified according to the diagnostic criteria for temporomandibular disorders (DC/TMD). Pain, pain-related disability and jaw function were also assessed. A clinical periodontal examination was performed. Subgingival plaque samples were collected and analyzed for semiquantitative levels of the following periodontal pathogens; Aggregatibacter actinomycetemcomintans, Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola.

RESULTS: No significant difference between JIA and healthy individuals was observed regarding the clinical periodontal variables plaque, gingivitis, probing pocket depth or the investigated periodontal pathogens. P. gingivalis and T. forsythia were detected in both groups. In the group with JIA, no significant correlation was found between orofacial pain, jaw function, systemic inflammatory activity and periodontal disease, including levels of P. gingivalis and T. forsythia. 

CONCLUSION: This study suggests that the periodontal disease-associated bacteria P. gingivalis and T. forsythia do not contribute to neither periodontal disease, systemic inflammatory activity nor orofacial pain and jaw dysfunction, including TMJ arthritis, in JIA patients in Sweden.

Place, publisher, year, edition, pages
Società Italiana di Odontoiatria Infantile, 2024
Keywords
Bacteria anaerobic, children, juvenile idiopathic arthritis, periodontal disease, temporomandibular joint disorders
National Category
Dentistry Pediatrics
Identifiers
urn:nbn:se:mau:diva-66263 (URN)10.23804/ejpd.2024.1913 (DOI)38353519 (PubMedID)2-s2.0-85185205970 (Scopus ID)
Available from: 2024-03-08 Created: 2024-03-08 Last updated: 2024-06-17Bibliographically approved
Dimitrijevic Carlsson, A., Wahlund, K., Klintström, E., Salé, H., Kindgren, E., Starkhammar Johansson, C. & Alstergren, P. (2023). Juvenile idiopathic arthritis and the temporomandibular joint: a case-control study of magnetic resonance imaging findings in relation to clinical and psychosocial factors.. European Journal of Paediatric Dentistry, 24(1), 69-76
Open this publication in new window or tab >>Juvenile idiopathic arthritis and the temporomandibular joint: a case-control study of magnetic resonance imaging findings in relation to clinical and psychosocial factors.
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2023 (English)In: European Journal of Paediatric Dentistry, ISSN 1591-996X, E-ISSN 2035-648X, Vol. 24, no 1, p. 69-76Article in journal (Refereed) Published
Abstract [en]

AIM: In juvenile idiopathic arthritis (JIA), the temporomandibular joint (TMJ) is a particularly challenging joint to assess both clinically and with imaging. The aim of this article is to investigate TMJ magnetic resonance imaging (MRI) findings in relation to clinical and psychosocial factors in patients with JIA and healthy individuals related to TMJ arthritis in JIA.

MATERIALS: In total, 45 patients (6-16 years) with JIA and 16 healthy age- and sex-matched controls were examined according to the diagnostic criteria for temporomandibular disorders (DC/TMD). The subjects answered questionnaires about psychosocial factors (pain intensity, pain-related disability, depression, stress, catastrophising, pain locations, and jaw function) and underwent bilateral MRI of the TMJ.

RESULTS: There were no significant differences between JIA patients and healthy individuals in any of the TMJ MRI findings. Moderate/severe changes among JIA patients were found only for effusion, synovial thickening, condylar flattening, and erosion, with no moderate/severe changes in healthy individuals. In JIA patients, orofacial pain intensity was related to TMJ bone marrow oedema, and pain in jaw muscles during jaw function was related to TMJ bone marrow oedema and erosion. There were no significant correlations between psychosocial aspects and MRI findings.

CONCLUSION: This study indicates a substantial overlap of TMJ MRI findings in both the inflammatory domain and the damage domain between JIA patients and healthy individuals. In JIA patients, the inflammatory MRI sign of bone marrow oedema seems to influence orofacial pain intensity.

Place, publisher, year, edition, pages
Società Italiana di Odontoiatria Infantile, 2023
National Category
Dentistry
Identifiers
urn:nbn:se:mau:diva-58549 (URN)10.23804/ejpd.2023.24.01.12 (DOI)000945146900012 ()36853210 (PubMedID)2-s2.0-85149154015 (Scopus ID)
Available from: 2023-03-03 Created: 2023-03-03 Last updated: 2024-06-18Bibliographically approved
Dimitrijevic Carlsson, A., Ghafouri, B., Starkhammar Johansson, C. & Alstergren, P. (2020). Unstimulated Parotid Saliva Sampling in Juvenile Idiopathic Arthritis and Healthy Controls: A Proof-of-Concept Study on Biomarkers. Diagnostics (Basel), 10(4), Article ID 251.
Open this publication in new window or tab >>Unstimulated Parotid Saliva Sampling in Juvenile Idiopathic Arthritis and Healthy Controls: A Proof-of-Concept Study on Biomarkers
2020 (English)In: Diagnostics (Basel), ISSN 2075-4418, Vol. 10, no 4, article id 251Article in journal (Refereed) Published
Abstract [en]

The aims of this proof-of-concept study were to develop a collecting method for unstimulated parotid saliva in juvenile idiopathic arthritis (JIA) patients and healthy children and to investigate if inflammatory biomarkers could be detected in these samples. Forty-five children with JIA (median age of 12 years and 25th-75th percentile of 10-15 years; 33 girls and 12 boys) and 16 healthy children as controls (median age of 13 years and 25-75th percentile of 10-13 years; 11 girls and 5 boys) were enrolled in this study. Unstimulated parotid saliva was collected with a modified Carlson-Crittenden collector. The salivary flow rate and salivary concentrations of total protein and inflammatory mediators were assessed. The Meso Scale Discovery electrochemiluminescence immunoassay was used for analyzing protein concentrations and the inflammatory biomarkers. Sufficient parotid saliva volumes to be analyzed could be collected with the collection device. JIA patients had a lower sampling saliva volume (p = 0.008) and saliva flow rate (p = 0.039) than controls. The total protein concentrations and inflammatory biomarkers were measured in the last six healthy subjects. The median protein concentration was 1312 mu g/mL (25th percentile: 844 mu g/mL and 75th percentile: 2062 mu g/mL; n = 6) and quantifiable concentrations of 39 inflammatory proteins could be assessed in these samples. In conclusion, this study indicates that the saliva sampling method, as used in the present study, is able to collect sufficient sample volumes in children, and that it is possible to analyze various inflammatory biomarkers in the collected saliva.

Place, publisher, year, edition, pages
MDPI, 2020
Keywords
biomarkers, children, juvenile idiopathic arthritis, parotid saliva, saliva collection
National Category
Pediatrics
Identifiers
urn:nbn:se:mau:diva-17517 (URN)10.3390/diagnostics10040251 (DOI)000534251000042 ()32344523 (PubMedID)2-s2.0-85083789706 (Scopus ID)
Available from: 2020-06-18 Created: 2020-06-18 Last updated: 2024-06-17Bibliographically approved
Carlsson, A. D., Wahlund, K., Kindgren, E., Skogh, T., Johansson, C. S. & Alstergren, P. (2019). Orofacial pain in juvenile idiopathic arthritis is associated with stress as well as psychosocial and functional limitations. Pediatric Rheumatology, 17(1), Article ID 83.
Open this publication in new window or tab >>Orofacial pain in juvenile idiopathic arthritis is associated with stress as well as psychosocial and functional limitations
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2019 (English)In: Pediatric Rheumatology, E-ISSN 1546-0096, Vol. 17, no 1, article id 83Article in journal (Refereed) Published
Abstract [en]

Background The aim of this study was to investigate relations between psychosocial factors, signs and symptoms of orofacial pain and jaw dysfunction in patients with juvenile idiopathic arthritis (JIA). Methods Forty-five patients with JIA (median age 12 years) and 16 healthy matched controls (median age 13 years) were examined according to the diagnostic criteria for temporomandibular disorders (DC/TMD). The subjects answered the DC/TMD questionnaires regarding psychosocial factors (pain intensity, pain-related disability, depression, stress, catastrophizing, pain locations and jaw function). Results JIA patients with orofacial pain had higher degree of stress, depression, catastrophizing and jaw dysfunction compared to subjects without. In turn, these factors were associated with orofacial pain intensity. Also, patients with orofacial pain had higher systemic inflammatory activity. Conclusions Orofacial pain in patients with JIA is associated with stress, psychological distress, jaw dysfunction and loss of daily living activities. Pain intensity seems to be the major pain aspect related to these factors. In addition, systemic inflammatory activity appears to be an important factor contributing to orofacial pain in JIA.

Place, publisher, year, edition, pages
BioMed Central (BMC), 2019
Keywords
Adolescents, Children, Juvenile idiopathic arthritis, Orofacial pain, Psychosocial, Stress Temporomandibular joint disorders
National Category
Rheumatology and Autoimmunity
Identifiers
urn:nbn:se:mau:diva-17239 (URN)10.1186/s12969-019-0385-7 (DOI)000512605400001 ()31856854 (PubMedID)2-s2.0-85077044869 (Scopus ID)
Available from: 2020-05-13 Created: 2020-05-13 Last updated: 2024-03-21Bibliographically approved
Dimitrijevic Carlsson, A., Wahlund, K., Ghafouri, B., Kindgren, E., Frodlund, M., Salé, H., . . . Alstergren, P.Parotid saliva and blood biomarkers in juvenile idiopathic arthritis inrelation to temporomandibular joint magnetic resonance imaging findings.
Open this publication in new window or tab >>Parotid saliva and blood biomarkers in juvenile idiopathic arthritis inrelation to temporomandibular joint magnetic resonance imaging findings
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(English)Manuscript (preprint) (Other academic)
National Category
Rheumatology and Autoimmunity Dentistry
Identifiers
urn:nbn:se:mau:diva-66389 (URN)
Funder
Medical Research Council of Southeast Sweden (FORSS)Region ÖstergötlandSwedish Dental Association
Available from: 2024-03-20 Created: 2024-03-20 Last updated: 2024-03-21Bibliographically approved
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ORCID iD: ORCID iD iconorcid.org/0000-0002-2260-8442

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